Mechanisms of lymphatic metastasis
نویسندگان
چکیده
منابع مشابه
Mechanisms of lymphatic metastasis.
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell sur...
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The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis. Changes in the adhesive properties of lymphatic endothelium near tumors may also fac...
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G are the most common malignant primary brain tumor. Only 0.2%-0.5% of cases metastasise outside the brain.1,2 We present a rare case of glioblastoma with bilateral cervical lymph node metastases. A 60-year-old man presented with 3-weeks of progressive right arm tingling. He had no medical history of note and the only abnormalities found on examination were decreased light touch and propriocept...
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The lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemination, it has remained unclear whether activation of lymphatic endothelial cells may affect tumor progression and metastasis and the molecul...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci71606